Specifically it is used to treat deep vein thrombosis and pulmonary emboli and prevent blood clots in atrial fibrillation and following hip or knee surgery. It is taken by mouth.
Common side effects include bleeding.
Other serious side effects may include spinal hematoma and anaphylaxis.
It is unclear if use in pregnancy and breastfeeding is safe.
Compared to warfarin it has fewer interactions with other medications.
It works by blocking the activity of the clotting protein factor Xa.
Rivaroxaban was patented in 2007 and approved for medical use in the United States in 2011.
In the United States, it will not be available as a generic medication until 2024.
It is on the World Health Organization’s List of Essential Medicines.
In 2019, it was the 91st most commonly prescribed medication in the United States, with more than 8 million prescriptions.